try to measure dtr to see if it works and the ft232rl is still functioning.
you can simply measure the RESET pin of the micro and then try the bootloader. you should see activity on the reset pin. (of course setting must be that DTR is used for reset)
when that does not work you could add a diode and a button to ground for the reset. i do assume the micro is not defective and still responds to a reset?
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